CV
RYO OZURU / 尾鶴 亮
Education and professional experience
Education
2011 B. S. (Biomedical Science), Department of Biomedical Science, Kyushu University School of Medicine, Fukuoka, Japan
2013 MSc (Systems Life Sciences), Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan
2017 Ph. D. (Medicine), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Dissertation title: “Adipose tissue is the first colonization site of Leptospira interrogans in subcutaneously infected hamsters” Advisor: Shin-ichi Yoshida, Emeritus Professor, Kyushu University
Faculty academic appointments
2015 Apr. – 2021 Mar., Assistant Professor, Division of Bacteriology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University, Japan
2021 Apr. - 2022 Sep., Assistant Professor, Department of Microbiology and Immunology, Faculty of Medicine, Fukuoka University, Japan
2022 Oct. - present, Senior Assistant Professor, Department of Microbiology and Immunology, Faculty of Medicine, Fukuoka University, Japan
Professional Societies
2012 – present, Japanese Society for Bacteriology. Member
2019 – present, Japanese Society for Bioinformatics. Member
Editorial activities
2021 - present, Review editor, Frontiers in Microbiology
Ad hoc reviewer
- Microbial Pathogenesis 2017
- PLoS Neglected Tropical Diseases 2017
- Archives of Microbiology 2019
Educational activities
- Bacteriology (Spirochetes) 2016 – 2021.
- Bacteriology (Mycoplasma) 2018 – 2021.
- Microbiology in Nursing 2016 – 2021.
- Microbiology (Spirochetes) 2021 – present.
- Microbiology (Chlamydia) 2022 – present.
Funding Information
Current
2021 – 2023.
Creation of a novel biomarker for leptospirosis using the adipose tissue colonization mechanism of Leptospira.
Project PI (4,550,000 JPY)
Japan Society for the Promotion of Science (JSPS)
Grants-in-Aid for Scientific Research: Early-Career Scientists (#21K16320)
Past
2018 – 2021.
Investigation of molecular mechanisms of leptospiral colonization on host adipose tissue.
Project PI (4,160,000 JPY)
Japan Society for the Promotion of Science (JSPS)
Grants-in-Aid for Scientific Research: Early-Career Scientists (#18K16174)
The major goal of this study is to find colonization factors of Leptospira in order to unravel molecular mechanisms of leptospiral colonization on adipose tissue of animals.
Bibliography
Peer-reviewed
*: corresponding author
†: equal contribution
- Kurihara Y, Walenna NF, Ishii K, Soejima T, Chou B, Yoshimura M, Ozuru R, et al. Chlamydia pneumoniae Lung Infection in Mice Induces Fatty Acid–Binding Protein 4–Dependent White Adipose Tissue Pathology. J Immunol. 2023; ji2200601.
- Obata F, Murota H, Shibata S, Ozuru R, Fujii J. Investigation of Bacteria from Spoiled Bottled Salad Dressing Leading to Gas Explosion. Yonago Acta Med. 2022;65: 207–214.
- Sakamoto A, Yoshimura M, Itoh R, Ozuru R, Ishii K, Sechi Y, et al. Longitudinal Dynamics of SARS-CoV-2 IgG Antibody Responses after the Two-Dose Regimen of BNT162b2 Vaccination and the Effect of a Third Dose on Healthcare Workers in Japan. Vaccines. 2022;10: 830.
- Xu J†, Koizumi N†, Morimoto YV†, Ozuru R, Masuzawa T, Nakamura S. Light dependent synthesis of a nucleotide second messenger controls the motility of a spirochete bacterium. Sci Rep. 2022;12: 6825.
- Obata F, Ozuru R, Tsuji T, Matsuba T, Fujii J. Stx2 Induces Differential Gene Expression and Disturbs Circadian Rhythm Genes in the Proximal Tubule. Toxins. 2022;14. doi:10.3390/toxins14020069
- Oyamada Y†, Ozuru R†*, Masuzawa T, Miyahara S, Nikaido Y, Obata F, et al. A machine learning model of microscopic agglutination test for diagnosis of leptospirosis. PLoS One. 2021;16: e0259907.
- Ozuru R, Wakao S, Tsuji T, Ohara N, Matsuba T, Amuran MY, et al. Rescue from Stx2-Producing E. coli-Associated Encephalopathy by Intravenous Injection of Muse Cells in NOD-SCID Mice. Mol Ther. 2020;28: 100–118.
- Bai G, Matsuba T, Kikuchi H, Chagan-Yasutan H, Motoda H, Ozuru R, et al. Inhibition of inflammatory-molecule synthesis in THP-1 cells stimulated with phorbol 12-myristate 13-acetate by brefelamide derivatives. Int Immunopharmacol. 2019;75: 105831.
- Bai G†, Motoda H†, Ozuru R†, Chagan-Yasutan H, Hattori T, Matsuba T. Synthesis of a Cleaved Form of Osteopontin by THP-1 Cells and Its Alteration by Phorbol 12-Myristate 13-Acetate and BCG Infection. Int J Mol Sci. 2018;19. doi:10.3390/ijms19020418
- Ozuru R*, Saito M, Kanemaru T, Miyahara S, Villanueva SYAM, Murray GL, et al. Adipose tissue is the first colonization site of Leptospira interrogans in subcutaneously infected hamsters. PLoS One. 2017;12: e0172973.
- Saito M, Villanueva SYAM, Masuzawa T, Haraguchi Y, Ita S, Miyahara S, et al. The usefulness of semi-solid medium in the isolation of highly virulent Leptospira strains from wild rats in an urban area of Fukuoka, Japan. Microbiol Immunol. 2015;59: 322–330.
- Saito M, Villanueva SYAM, Chakraborty A, Miyahara S, Segawa T, Asoh T, et al. Comparative analysis of Leptospira strains isolated from environmental soil and water in the Philippines and Japan. Appl Environ Microbiol. 2013;79: 601–609.
Presentations
International
Oral presentation
2016, The 15th Awaji International Forum on Infection and Immunity, Hyogo, Japan.
2017, The International Leptospirosis Society Scientific Meeting, Palmerston North, New Zealand.
2018, 10th International Symposium on Shiga Toxin Producing E. coli Infections, Florence, Italy.
2019, 21st International Conference On Emerging Infectious Diseases In The Pacific Rim, Hanoi, Vietnam.
2019, 22nd International Conference On Emerging Infectious Diseases In The Pacific Rim, Osaka, Japan.
2022, The International Leptospirosis Society Scientific Meeting, Bangkok, Thailand.
Poster presentation
2019, The International Leptospirosis Society Scientific Meeting, Vancouver, Canada.
Domestic (Invited)
2018, The 171st Biomechanics Research Meeting
2021, The 94th Annual Meeting of Japanese Society for Bacteriology.
2022, The 95th Annual Meeting of Japanese Society for Bacteriology.
2023, The 96th Annual Meeting of Japanese Society for Bacteriology.